Supported by the Knowledge Innovation Project of the Chinese Academy of Sciences and the National Natural Science Foundation of China, the National Microgravity Laboratory at the Institute of Mechanics has, after years of dedicated research, successfully developed the "Protein Chip Biosensor System" along with its practical prototype. This innovative system integrates multiple protein-based microarrays, specific biomolecular binding, and high-resolution ellipsometry optical imaging technology, offering a novel label-free approach for protein analysis.
The biosensor system is designed to detect target molecules using a single non-labeling reagent, which helps preserve the biological activity of the proteins, minimizes non-specific signals, and enhances the sensitivity of detecting molecular interactions. It provides real-time, intuitive results and includes a feature for distinguishing false signals. The system integrates protein solution transport, chip preparation, and interaction within a single microchannel reactor, featuring 48 independent units that allow for simultaneous detection of multiple samples and indicators. This significantly reduces both testing time and sample consumption.
Moreover, the system requires minimal chip fabrication costs, as only reagents are needed during operation. For instance, when detecting five hepatitis B markers, traditional enzyme-linked immunosorbent assays (ELISA) take at least one day, while the new system completes the process in just 40 minutes, greatly improving efficiency. Additionally, it only needs tens of microliters of blood instead of several milliliters, making it highly efficient and less invasive.
Due to its high-throughput capabilities, the device is suitable for various applications, including protein profiling, disease marker identification, and drug screening. It has already been successfully applied in experiments such as the simultaneous detection of hepatitis B markers, tumor markers, trace antigens, SARS antibodies, viral detection, and acute cardiac infarction diagnostics. These achievements highlight its broad potential in the biomedical field.
At the appraisal meeting held on July 5, experts, including Academician Zhang Shuyi, praised the system for its high level of automation and integration, noting that it reaches international advanced standards. This innovation marks a significant step forward in biosensing technology, promising transformative impacts in healthcare and life sciences.
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